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Moreover, subgroup analysis showed that the target population, ethnicity and the mean age of participants, the number and type of probiotic strains, administration form, and the dose and duration of pro-/synbiotic supplementation were the potential sources of heterogeneity between RCTs. TheBrain Pro includes advanced layouts so you can see more at once. The meta-analysis revealed that supplementation with pro-/synbiotics significantly increased BDNF concentrations in comparison with the placebo (WMD: 0.20 ng mL −1, 95% CI: 0.06 to 0.34, I 2 = 86.6%). In the present study, 10 RCTs with 12 treatment arms consisting of 652 participants were included. With TheBrain youre never more than a few. The weighted mean difference (WMD) and 95% confidence interval (CI) were computed for BDNF using a random-effects model. With TheBrain, your digital Brain captures all that intelligence for playback just when you need it. Scopus, Medline, Web of Science, Cochrane Library, and Google Scholar were searched up to Jto find eligible RCTs.
Therefore, we aimed to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to investigate the impact of pro-/synbiotic supplementation on BDNF levels. Animal studies have reported that pro-/synbiotic administration can increase the brain-derived neurotrophic factor (BDNF), a key regulator of neuronal function. Nevertheless, the results obtained from human studies are inconsistent and conflicting. Animal studies have reported that pro-/synbiotic administration can increase the brain-derived neurotrophic factor (BDNF), a key regulator of neuronal function. There is growing interest in supplementation with pro-/synbiotics for brain and mental health.
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